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CTLA-4 Engagement Inhibits Th2 but not Th1 Cell Polarisation

CTLA-4 deficient mice show severe lymphoproliferative disorders with T helper sub-population skewed toward the Th2 phenotype. In the present work, we investigated the role of CTLA-4 in T helper cell subset differentiation. Naïve CD4(+) cells were stimulated with anti-CD3 and anti-CD28 mAbs in the pr...

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Detalles Bibliográficos
Autores principales:	Ubaldi, Vanessa, Gatta, Lucia, Pace, Luigia, Doria, Gino, Pioli, Claudio
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2003
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270672/ https://www.ncbi.nlm.nih.gov/pubmed/14575153 http://dx.doi.org/10.1080/10446670310001598519

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