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Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity
Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270759/ https://www.ncbi.nlm.nih.gov/pubmed/17162368 http://dx.doi.org/10.1080/17402520600834704 |
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author | Li, Alice Ojogho, Okechukwu Escher, Alan |
author_facet | Li, Alice Ojogho, Okechukwu Escher, Alan |
author_sort | Li, Alice |
collection | PubMed |
description | Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity of APCs like macrophages and DCs to induce and maintain tolerance after phagocytosis of dead cells. Processing of apoptotic cells by DCs is of particular interest, because DCs are the only known APCs capable of activating naïve T lymphocytes to become effector or regulatory cells. In that regard, recent evidence suggests that phagocytosis of apoptotic cells by DCs can induce Tregs, a finding that has significant implications for the treatment of a variety of immune-mediated inflammatory disorders. Here, we review the relationship between apoptotic cells, DCs, and Tregs, and its impact on prevention of transplant rejection and treatment of autoimmune diseases. |
format | Text |
id | pubmed-2270759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22707592008-03-31 Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity Li, Alice Ojogho, Okechukwu Escher, Alan Clin Dev Immunol Research Article Long considered immunologically “bland,” apoptotic cells are now recognized as important modulators of immune responses. The role of apoptosis in immunological homeostasis has been inferred from several findings, for example, induction of tolerance after injection of apoptotic cells and the capacity of APCs like macrophages and DCs to induce and maintain tolerance after phagocytosis of dead cells. Processing of apoptotic cells by DCs is of particular interest, because DCs are the only known APCs capable of activating naïve T lymphocytes to become effector or regulatory cells. In that regard, recent evidence suggests that phagocytosis of apoptotic cells by DCs can induce Tregs, a finding that has significant implications for the treatment of a variety of immune-mediated inflammatory disorders. Here, we review the relationship between apoptotic cells, DCs, and Tregs, and its impact on prevention of transplant rejection and treatment of autoimmune diseases. Hindawi Publishing Corporation 2006 /pmc/articles/PMC2270759/ /pubmed/17162368 http://dx.doi.org/10.1080/17402520600834704 Text en Copyright © 2006 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Alice Ojogho, Okechukwu Escher, Alan Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
title | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
title_full | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
title_fullStr | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
title_full_unstemmed | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
title_short | Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity |
title_sort | saving death: apoptosis for intervention in transplantation and autoimmunity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270759/ https://www.ncbi.nlm.nih.gov/pubmed/17162368 http://dx.doi.org/10.1080/17402520600834704 |
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