Serum Reactivity Against Bacterial Pyruvate Dehydrogenase: Increasing the Specificity of Anti-Mitochondrial Antibodies for the Diagnosis of Primary Biliary Cirrhosis

Antimitochondrial antibodies (AMA) are the serum hallmark of primary biliary cirrhosis (PBC). However, AMA-positivity can be found in non-PBC sera when lower dilutions are used, thus raising issues about the specificity and sensitivity of the test. AMA reacts primarily with the lipoylated domains of...

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Detalles Bibliográficos
Autores principales: Miyakawa, Hiroshi, Tanaka, Atsushi, Selmi, Carlo, Hosoya, Naomi, Mataki, Norikazu, Kikuchi, Kentaro, Kato, Takashi, Arai, Junya, Goto, Toshihiro, Gershwin, M. Eric
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270775/
https://www.ncbi.nlm.nih.gov/pubmed/17162370
http://dx.doi.org/10.1080/17402520600668706

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