NK Cells and Type 1 Diabetes

Type 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps o...

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Detalles Bibliográficos
Autores principales: Rodacki, Melanie, Milech, Adolpho, de Oliveira, José Egídio Paulo
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270779/
https://www.ncbi.nlm.nih.gov/pubmed/17162353
http://dx.doi.org/10.1080/17402520600877182
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author Rodacki, Melanie
Milech, Adolpho
de Oliveira, José Egídio Paulo
author_facet Rodacki, Melanie
Milech, Adolpho
de Oliveira, José Egídio Paulo
author_sort Rodacki, Melanie
collection PubMed
description Type 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps of the immune-mediated attack that leads to T1D. Abnormalities in the frequency and activity of NK cells have been described both in animal models and patients with T1D. Some of these alterations are linked to its onset while others seem to be a consequence of the disease. Here, we discuss the main characteristics of NK cells and review the studies that investigated the role of NK cells in T1D, both in mouse models and humans.
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spelling pubmed-22707792008-03-31 NK Cells and Type 1 Diabetes Rodacki, Melanie Milech, Adolpho de Oliveira, José Egídio Paulo Clin Dev Immunol Research Article Type 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps of the immune-mediated attack that leads to T1D. Abnormalities in the frequency and activity of NK cells have been described both in animal models and patients with T1D. Some of these alterations are linked to its onset while others seem to be a consequence of the disease. Here, we discuss the main characteristics of NK cells and review the studies that investigated the role of NK cells in T1D, both in mouse models and humans. Hindawi Publishing Corporation 2006 /pmc/articles/PMC2270779/ /pubmed/17162353 http://dx.doi.org/10.1080/17402520600877182 Text en Copyright © 2006 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rodacki, Melanie
Milech, Adolpho
de Oliveira, José Egídio Paulo
NK Cells and Type 1 Diabetes
title NK Cells and Type 1 Diabetes
title_full NK Cells and Type 1 Diabetes
title_fullStr NK Cells and Type 1 Diabetes
title_full_unstemmed NK Cells and Type 1 Diabetes
title_short NK Cells and Type 1 Diabetes
title_sort nk cells and type 1 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270779/
https://www.ncbi.nlm.nih.gov/pubmed/17162353
http://dx.doi.org/10.1080/17402520600877182
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AT deoliveirajoseegidiopaulo nkcellsandtype1diabetes

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