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Current Perspectives on Primary Immunodeficiency Diseases
Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Desp...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270780/ https://www.ncbi.nlm.nih.gov/pubmed/17162365 http://dx.doi.org/10.1080/17402520600800705 |
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author | Kumar, Arvind Teuber, Suzanne S. Gershwin, M. Eric |
author_facet | Kumar, Arvind Teuber, Suzanne S. Gershwin, M. Eric |
author_sort | Kumar, Arvind |
collection | PubMed |
description | Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Despite the heritable nature of these diseases, some PIDs are clinically manifested only after prerequisite environmental exposures but they often have associated malignant, allergic, or autoimmune manifestations. PIDs must be distinguished from secondary or acquired immunodeficiencies, which are far more common. In this review, we will place these immunodeficiencies in the context of both clinical and laboratory presentations as well as highlight the known genetic basis. |
format | Text |
id | pubmed-2270780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22707802008-03-31 Current Perspectives on Primary Immunodeficiency Diseases Kumar, Arvind Teuber, Suzanne S. Gershwin, M. Eric Clin Dev Immunol Research Article Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Despite the heritable nature of these diseases, some PIDs are clinically manifested only after prerequisite environmental exposures but they often have associated malignant, allergic, or autoimmune manifestations. PIDs must be distinguished from secondary or acquired immunodeficiencies, which are far more common. In this review, we will place these immunodeficiencies in the context of both clinical and laboratory presentations as well as highlight the known genetic basis. Hindawi Publishing Corporation 2006 /pmc/articles/PMC2270780/ /pubmed/17162365 http://dx.doi.org/10.1080/17402520600800705 Text en Copyright © 2006 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kumar, Arvind Teuber, Suzanne S. Gershwin, M. Eric Current Perspectives on Primary Immunodeficiency Diseases |
title | Current Perspectives on Primary Immunodeficiency Diseases |
title_full | Current Perspectives on Primary Immunodeficiency Diseases |
title_fullStr | Current Perspectives on Primary Immunodeficiency Diseases |
title_full_unstemmed | Current Perspectives on Primary Immunodeficiency Diseases |
title_short | Current Perspectives on Primary Immunodeficiency Diseases |
title_sort | current perspectives on primary immunodeficiency diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270780/ https://www.ncbi.nlm.nih.gov/pubmed/17162365 http://dx.doi.org/10.1080/17402520600800705 |
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