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Current Perspectives on Primary Immunodeficiency Diseases

Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Desp...

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Detalles Bibliográficos
Autores principales: Kumar, Arvind, Teuber, Suzanne S., Gershwin, M. Eric
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270780/
https://www.ncbi.nlm.nih.gov/pubmed/17162365
http://dx.doi.org/10.1080/17402520600800705
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author Kumar, Arvind
Teuber, Suzanne S.
Gershwin, M. Eric
author_facet Kumar, Arvind
Teuber, Suzanne S.
Gershwin, M. Eric
author_sort Kumar, Arvind
collection PubMed
description Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Despite the heritable nature of these diseases, some PIDs are clinically manifested only after prerequisite environmental exposures but they often have associated malignant, allergic, or autoimmune manifestations. PIDs must be distinguished from secondary or acquired immunodeficiencies, which are far more common. In this review, we will place these immunodeficiencies in the context of both clinical and laboratory presentations as well as highlight the known genetic basis.
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spelling pubmed-22707802008-03-31 Current Perspectives on Primary Immunodeficiency Diseases Kumar, Arvind Teuber, Suzanne S. Gershwin, M. Eric Clin Dev Immunol Research Article Since the original description of X-linked agammaglobulinemia in 1952, the number of independent primary immunodeficiency diseases (PIDs) has expanded to more than 100 entities. By definition, a PID is a genetically determined disorder resulting in enhanced susceptibility to infectious disease. Despite the heritable nature of these diseases, some PIDs are clinically manifested only after prerequisite environmental exposures but they often have associated malignant, allergic, or autoimmune manifestations. PIDs must be distinguished from secondary or acquired immunodeficiencies, which are far more common. In this review, we will place these immunodeficiencies in the context of both clinical and laboratory presentations as well as highlight the known genetic basis. Hindawi Publishing Corporation 2006 /pmc/articles/PMC2270780/ /pubmed/17162365 http://dx.doi.org/10.1080/17402520600800705 Text en Copyright © 2006 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kumar, Arvind
Teuber, Suzanne S.
Gershwin, M. Eric
Current Perspectives on Primary Immunodeficiency Diseases
title Current Perspectives on Primary Immunodeficiency Diseases
title_full Current Perspectives on Primary Immunodeficiency Diseases
title_fullStr Current Perspectives on Primary Immunodeficiency Diseases
title_full_unstemmed Current Perspectives on Primary Immunodeficiency Diseases
title_short Current Perspectives on Primary Immunodeficiency Diseases
title_sort current perspectives on primary immunodeficiency diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270780/
https://www.ncbi.nlm.nih.gov/pubmed/17162365
http://dx.doi.org/10.1080/17402520600800705
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