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Isoflavones prevent bone loss following ovariectomy in young adult rats
Soy protein, a rich source of phytoestrogens, exhibit estrogen-type bioactivity. The purpose of this study was to determine if ingestion of isoflavones before ovariectomy can prevent bone loss following ovariectomy. Twenty-four nulliparous Wistar rats were randomly divided into four groups. In the n...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270812/ https://www.ncbi.nlm.nih.gov/pubmed/18312690 http://dx.doi.org/10.1186/1749-799X-3-12 |
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author | Tsuang, Yang-Hwei Chen, Li-Ting Chiang, Chang-Jung Wu, Lien-Chen Chiang, Yueh-Feng Chen, Pei-Yu Sun, Jui-Sheng Wang, Chien-Che |
author_facet | Tsuang, Yang-Hwei Chen, Li-Ting Chiang, Chang-Jung Wu, Lien-Chen Chiang, Yueh-Feng Chen, Pei-Yu Sun, Jui-Sheng Wang, Chien-Che |
author_sort | Tsuang, Yang-Hwei |
collection | PubMed |
description | Soy protein, a rich source of phytoestrogens, exhibit estrogen-type bioactivity. The purpose of this study was to determine if ingestion of isoflavones before ovariectomy can prevent bone loss following ovariectomy. Twenty-four nulliparous Wistar rats were randomly divided into four groups. In the normal diet groups, a sham operation was performed on Group A, while ovariectomy was performed on Group B. For Groups C and D, all rats were fed with an isoflavone-rich (25 mg/day) diet for one month, then bilateral ovariectomy were performed. In the rats in Group C, a normal diet was begun following the ovariectomy. The rats in Groups D continued to receive the isoflavone-rich diet for two additional months postoperatively. All rats were sacrificed 60 days after surgery. The weight of bone ash of the long bones and whole lumbar spine were determined. A histological study of cancellous bone was done and biochemical indices of skeletal metabolism were performed and analyzed. The markers of bone metabolism exhibited no significant changes. When compared with the sham-operated rats fed a normal diet, the bone mass of ovariectomized rats decreased significantly; pre-ovariectomy ingestion of an isoflavone-rich diet did not prevent bone loss. The bone mass of rats treated with an isoflavone-rich diet for three months was higher than controls two months after ovariectomy. Dietary isoflavones did not prevent the development of post-ovariectomy bone loss, but long-term ingestion of an isoflavone-rich diet increased the bone mineral contents after ovariectomy in young rats. |
format | Text |
id | pubmed-2270812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22708122008-03-21 Isoflavones prevent bone loss following ovariectomy in young adult rats Tsuang, Yang-Hwei Chen, Li-Ting Chiang, Chang-Jung Wu, Lien-Chen Chiang, Yueh-Feng Chen, Pei-Yu Sun, Jui-Sheng Wang, Chien-Che J Orthop Surg Research Article Soy protein, a rich source of phytoestrogens, exhibit estrogen-type bioactivity. The purpose of this study was to determine if ingestion of isoflavones before ovariectomy can prevent bone loss following ovariectomy. Twenty-four nulliparous Wistar rats were randomly divided into four groups. In the normal diet groups, a sham operation was performed on Group A, while ovariectomy was performed on Group B. For Groups C and D, all rats were fed with an isoflavone-rich (25 mg/day) diet for one month, then bilateral ovariectomy were performed. In the rats in Group C, a normal diet was begun following the ovariectomy. The rats in Groups D continued to receive the isoflavone-rich diet for two additional months postoperatively. All rats were sacrificed 60 days after surgery. The weight of bone ash of the long bones and whole lumbar spine were determined. A histological study of cancellous bone was done and biochemical indices of skeletal metabolism were performed and analyzed. The markers of bone metabolism exhibited no significant changes. When compared with the sham-operated rats fed a normal diet, the bone mass of ovariectomized rats decreased significantly; pre-ovariectomy ingestion of an isoflavone-rich diet did not prevent bone loss. The bone mass of rats treated with an isoflavone-rich diet for three months was higher than controls two months after ovariectomy. Dietary isoflavones did not prevent the development of post-ovariectomy bone loss, but long-term ingestion of an isoflavone-rich diet increased the bone mineral contents after ovariectomy in young rats. BioMed Central 2008-03-02 /pmc/articles/PMC2270812/ /pubmed/18312690 http://dx.doi.org/10.1186/1749-799X-3-12 Text en Copyright © 2008 Tsuang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tsuang, Yang-Hwei Chen, Li-Ting Chiang, Chang-Jung Wu, Lien-Chen Chiang, Yueh-Feng Chen, Pei-Yu Sun, Jui-Sheng Wang, Chien-Che Isoflavones prevent bone loss following ovariectomy in young adult rats |
title | Isoflavones prevent bone loss following ovariectomy in young adult rats |
title_full | Isoflavones prevent bone loss following ovariectomy in young adult rats |
title_fullStr | Isoflavones prevent bone loss following ovariectomy in young adult rats |
title_full_unstemmed | Isoflavones prevent bone loss following ovariectomy in young adult rats |
title_short | Isoflavones prevent bone loss following ovariectomy in young adult rats |
title_sort | isoflavones prevent bone loss following ovariectomy in young adult rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270812/ https://www.ncbi.nlm.nih.gov/pubmed/18312690 http://dx.doi.org/10.1186/1749-799X-3-12 |
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