Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates

Loss of function mutations in the receptor tyrosine kinase TrkB pathway resulted in hyperphagia and morbid obesity in human and rodents. Conversely, peripheral or central stimulation of TrkB by its natural ligands BDNF or NT4 reduced body weight and food intake in mice, supporting the idea that TrkB...

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Detalles Bibliográficos
Autores principales: Lin, John C., Tsao, David, Barras, Paul, Bastarrachea, Raul A., Boyd, Bob, Chou, Joyce, Rosete, Rodnie, Long, Hua, Forgie, Alison, Abdiche, Yasmina, Dilley, Jeanette, Stratton, Jennifer, Garcia, Carlos, Sloane, David L., Comuzzie, Anthony G., Rosenthal, Arnon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270901/
https://www.ncbi.nlm.nih.gov/pubmed/18382675
http://dx.doi.org/10.1371/journal.pone.0001900

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