Inciting inflammation: the RAGE about tumor promotion

Mechanisms of innate and adaptive immunity play a pivotal role in the development of cancer. Chronic inflammation can drive tumor development, but antitumor immunity can also restrict or even prevent tumor growth. New data show that feed-forward signals downstream of the receptor for advanced glycat...

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Detalles Bibliográficos
Autores principales: Dougan, Michael, Dranoff, Glenn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271001/
https://www.ncbi.nlm.nih.gov/pubmed/18268042
http://dx.doi.org/10.1084/jem.20080136
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author Dougan, Michael
Dranoff, Glenn
author_facet Dougan, Michael
Dranoff, Glenn
author_sort Dougan, Michael
collection PubMed
description Mechanisms of innate and adaptive immunity play a pivotal role in the development of cancer. Chronic inflammation can drive tumor development, but antitumor immunity can also restrict or even prevent tumor growth. New data show that feed-forward signals downstream of the receptor for advanced glycation end-products (RAGE) can fuel chronic inflammation, creating a microenvironment that is ideal for tumor formation.
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spelling pubmed-22710012008-08-18 Inciting inflammation: the RAGE about tumor promotion Dougan, Michael Dranoff, Glenn J Exp Med Commentaries Mechanisms of innate and adaptive immunity play a pivotal role in the development of cancer. Chronic inflammation can drive tumor development, but antitumor immunity can also restrict or even prevent tumor growth. New data show that feed-forward signals downstream of the receptor for advanced glycation end-products (RAGE) can fuel chronic inflammation, creating a microenvironment that is ideal for tumor formation. The Rockefeller University Press 2008-02-18 /pmc/articles/PMC2271001/ /pubmed/18268042 http://dx.doi.org/10.1084/jem.20080136 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Dougan, Michael
Dranoff, Glenn
Inciting inflammation: the RAGE about tumor promotion
title Inciting inflammation: the RAGE about tumor promotion
title_full Inciting inflammation: the RAGE about tumor promotion
title_fullStr Inciting inflammation: the RAGE about tumor promotion
title_full_unstemmed Inciting inflammation: the RAGE about tumor promotion
title_short Inciting inflammation: the RAGE about tumor promotion
title_sort inciting inflammation: the rage about tumor promotion
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271001/
https://www.ncbi.nlm.nih.gov/pubmed/18268042
http://dx.doi.org/10.1084/jem.20080136
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