PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

Plasmacytoid predendritic cells (pDCs) are the main producers of type I interferon (IFN) in response to Toll-like receptor (TLR) stimulation. Phosphatidylinositol-3 kinase (PI3K) has been shown to be activated by TLR triggering in multiple cell types; however, its role in pDC function is not known....

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Detalles Bibliográficos
Autores principales: Guiducci, Cristiana, Ghirelli, Cristina, Marloie-Provost, Marie-Annick, Matray, Tracy, Coffman, Robert L., Liu, Yong-Jun, Barrat, Franck J., Soumelis, Vassili
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271003/
https://www.ncbi.nlm.nih.gov/pubmed/18227218
http://dx.doi.org/10.1084/jem.20070763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271003/
https://www.ncbi.nlm.nih.gov/pubmed/18227218
http://dx.doi.org/10.1084/jem.20070763

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