An antidote for Staphylococcus aureus pneumonia?

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Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial infections in the United States. Severe invasive MRSA infections, which include pneumonia, are difficult to treat because the bacteria are resistant to antibiotics. A new report now shows that immunization against α...

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Detalles Bibliográficos
Autores principales: DeLeo, Frank R., Otto, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271020/
https://www.ncbi.nlm.nih.gov/pubmed/18268043
http://dx.doi.org/10.1084/jem.20080167
Descripción
Sumario:Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial infections in the United States. Severe invasive MRSA infections, which include pneumonia, are difficult to treat because the bacteria are resistant to antibiotics. A new report now shows that immunization against α-hemolysin (Hla), a cytolytic toxin secreted by most S. aureus strains, protects mice against lethal pneumonia. This finding represents the first successful vaccine strategy for the treatment of staphylococcal pneumonia.

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