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β-Globin LCR and Intron Elements Cooperate and Direct Spatial Reorganization for Gene Therapy

The Locus Control Region (LCR) requires intronic elements within β-globin transgenes to direct high level expression at all ectopic integration sites. However, these essential intronic elements cannot be transmitted through retrovirus vectors and their deletion may compromise the therapeutic potenti...

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Detalles Bibliográficos
Autores principales:	Buzina, Alla, Lo, Mandy Y. M., Moffett, Angela, Hotta, Akitsu, Fussner, Eden, Bharadwaj, Rikki R., Pasceri, Peter, Garcia-Martinez, J. Victor, Bazett-Jones, David P., Ellis, James
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2271131/ https://www.ncbi.nlm.nih.gov/pubmed/18404216 http://dx.doi.org/10.1371/journal.pgen.1000051

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