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Neutrophil-Dependent Oxidative Stress in Ulcerative Colitis

Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in ulcerative colitis (UC). Current advances have defined the mechanisms by which neutrophils are activated or migrate across mucosal epithelia. A be...

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Detalles Bibliográficos
Autores principales: Naito, Yuji, Takagi, Tomohisa, Yoshikawa, Toshikazu
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274988/
https://www.ncbi.nlm.nih.gov/pubmed/18392100
http://dx.doi.org/10.3164/jcbn.2007003
Descripción
Sumario:Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in ulcerative colitis (UC). Current advances have defined the mechanisms by which neutrophils are activated or migrate across mucosal epithelia. A better understanding of this process will likely provide new insights into novel treatment strategies for UC. Especially, activated neutrophils produce reactive oxygen and nitrogen species within intestinal mucosa, which induce oxidative stress. In clinically, we have succeeded to develop a novel granulocytes adsorptive apheresis therapy for UC. In this article, we discuss current advances to define the role of neutrophils-dependent oxidative stress in UC.