Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNA

Lon is an ATP-powered protease that binds DNA. However, the function of DNA binding by Lon remains elusive. Studies suggest that human Lon (hLon) binds preferentially to a G-rich single-stranded DNA (ssDNA) sequence overlapping the light strand promoter of mitochondrial DNA. This sequence is contain...

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Detalles Bibliográficos
Autores principales: Chen, Si-Han, Suzuki, Carolyn K., Wu, Shih-Hsiung
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275097/
https://www.ncbi.nlm.nih.gov/pubmed/18174225
http://dx.doi.org/10.1093/nar/gkm1140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275097/
https://www.ncbi.nlm.nih.gov/pubmed/18174225
http://dx.doi.org/10.1093/nar/gkm1140

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