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Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation
The selective and potent inhibition of mitochondrial translation in Saccharomyces cerevisiae by pentamidine suggests a novel antimicrobial action for this drug. Electrophoresis mobility shift assay, T1 ribonuclease footprinting, hydroxyl radical footprinting and isothermal titration calorimetry coll...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275129/ https://www.ncbi.nlm.nih.gov/pubmed/18263620 http://dx.doi.org/10.1093/nar/gkm1180 |