Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors

The hepatitis C virus (HCV) NS5B is essential for viral RNA replication and is therefore a prime target for development of HCV replication inhibitors. Here, we report the identification of a new class of HCV NS5B inhibitors belonging to the coumestan family of phytoestrogens. Based on the in vitro N...

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Detalles Bibliográficos
Autores principales: Kaushik-Basu, Neerja, Bopda-Waffo, Alain, Talele, Tanaji T., Basu, Amartya, Costa, Paulo R. R., da Silva, Alcides J. M., Sarafianos, Stefan G., Noël, François
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275130/
https://www.ncbi.nlm.nih.gov/pubmed/18203743
http://dx.doi.org/10.1093/nar/gkm1178

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