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The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site

Ribosome biogenesis in eukaryotes requires the participation of a large number of ribosome assembly factors. The highly conserved eukaryotic nucleolar protein Nep1 has an essential but unknown function in 18S rRNA processing and ribosome biogenesis. In Saccharomyces cerevisiae the malfunction of a t...

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Detalles Bibliográficos
Autores principales:	Taylor, Alexander B., Meyer, Britta, Leal, Belinda Z., Kötter, Peter, Schirf, Virgil, Demeler, Borries, Hart, P. John, Entian, Karl-Dieter, Wöhnert, Jens
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275143/ https://www.ncbi.nlm.nih.gov/pubmed/18208838 http://dx.doi.org/10.1093/nar/gkm1172

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