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Insights into structure, dynamics and hydration of locked nucleic acid (LNA) strand-based duplexes from molecular dynamics simulations
Locked nucleic acid (LNA) is a chemically modified nucleic acid with its sugar ring locked in an RNA-like (C3′-endo) conformation. LNAs show extraordinary thermal stabilities when hybridized with DNA, RNA or LNA itself. We performed molecular dynamics simulations on five isosequential duplexes (LNA–...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275159/ https://www.ncbi.nlm.nih.gov/pubmed/18203740 http://dx.doi.org/10.1093/nar/gkm1182 |