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The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma
BACKGROUND: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275292/ https://www.ncbi.nlm.nih.gov/pubmed/18226270 http://dx.doi.org/10.1186/1742-6405-5-2 |
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author | Feller, L Masipa, JN Wood, NH Raubenheimer, EJ Lemmer, J |
author_facet | Feller, L Masipa, JN Wood, NH Raubenheimer, EJ Lemmer, J |
author_sort | Feller, L |
collection | PubMed |
description | BACKGROUND: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. RESULTS AND CONCLUSION: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis. |
format | Text |
id | pubmed-2275292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22752922008-03-26 The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma Feller, L Masipa, JN Wood, NH Raubenheimer, EJ Lemmer, J AIDS Res Ther Case Report BACKGROUND: Kaposi Sarcoma (KS) is a multifocal angioproliferative neoplasm characterized by inflammation, oedema, neoangiogenesis and spindle cell proliferation. The pathogenesis of human immunodeficiency virus (HIV)-associated KS (HIV-KS) is multifactorial. HHV-8 is an essential factor but not in itself sufficient to cause HIV-KS, the development of which is influenced by HIV, by increased production of cytokines and by growth factors. Whether HIV-KS is a true malignancy or a reactive hyperplastic inflammatory condition is debatable. RESULTS AND CONCLUSION: Oedema of the face, legs and hands is a prominent feature of HIV-KS and is probably caused by lymphoedema related to the HIV-KS lesions. The cases of two HIV-seropositive subjects with KS-associated facial lymphoedema are reported. Extensive oral HIV-KS in association with facial oedema in the absence of anti-retroviral treatment appears to be an indication of a poor prognosis. BioMed Central 2008-01-29 /pmc/articles/PMC2275292/ /pubmed/18226270 http://dx.doi.org/10.1186/1742-6405-5-2 Text en Copyright © 2008 Feller et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Feller, L Masipa, JN Wood, NH Raubenheimer, EJ Lemmer, J The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma |
title | The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma |
title_full | The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma |
title_fullStr | The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma |
title_full_unstemmed | The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma |
title_short | The prognostic significance of facial lymphoedema in HIV-seropositive subjects with Kaposi sarcoma |
title_sort | prognostic significance of facial lymphoedema in hiv-seropositive subjects with kaposi sarcoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275292/ https://www.ncbi.nlm.nih.gov/pubmed/18226270 http://dx.doi.org/10.1186/1742-6405-5-2 |
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