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Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection
Therapeutic vaccination is a potentially promising strategy to enhance T cell immunity and viral control in chronically infected individuals. However, therapeutic vaccination approaches have fallen short of expectations, and effective boosting of antiviral T cell responses has not always been observ...
Autores principales: | Ha, Sang-Jun, Mueller, Scott N., Wherry, E. John, Barber, Daniel L., Aubert, Rachael D., Sharpe, Arlene H., Freeman, Gordon J., Ahmed, Rafi |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275378/ https://www.ncbi.nlm.nih.gov/pubmed/18332181 http://dx.doi.org/10.1084/jem.20071949 |
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