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Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonst...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275382/ https://www.ncbi.nlm.nih.gov/pubmed/18299402 http://dx.doi.org/10.1084/jem.20072108 |
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author | O'Connell, Ryan M. Rao, Dinesh S. Chaudhuri, Aadel A. Boldin, Mark P. Taganov, Konstantin D. Nicoll, John Paquette, Ronald L. Baltimore, David |
author_facet | O'Connell, Ryan M. Rao, Dinesh S. Chaudhuri, Aadel A. Boldin, Mark P. Taganov, Konstantin D. Nicoll, John Paquette, Ronald L. Baltimore, David |
author_sort | O'Connell, Ryan M. |
collection | PubMed |
description | Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating the sufficiency of miR-155 to drive GM expansion, enforced expression in mouse bone marrow cells caused GM proliferation in a manner reminiscent of LPS treatment. However, the miR-155–induced GM populations displayed pathological features characteristic of myeloid neoplasia. Of possible relevance to human disease, miR-155 was found to be overexpressed in the bone marrow of patients with certain subtypes of acute myeloid leukemia (AML). Furthermore, miR-155 repressed a subset of genes implicated in hematopoietic development and disease. These data implicate miR-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML, emphasizing the importance of proper miR-155 regulation in developing myeloid cells during times of inflammatory stress. |
format | Text |
id | pubmed-2275382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22753822008-09-17 Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder O'Connell, Ryan M. Rao, Dinesh S. Chaudhuri, Aadel A. Boldin, Mark P. Taganov, Konstantin D. Nicoll, John Paquette, Ronald L. Baltimore, David J Exp Med Articles Mammalian microRNAs are emerging as key regulators of the development and function of the immune system. Here, we report a strong but transient induction of miR-155 in mouse bone marrow after injection of bacterial lipopolysaccharide (LPS) correlated with granulocyte/monocyte (GM) expansion. Demonstrating the sufficiency of miR-155 to drive GM expansion, enforced expression in mouse bone marrow cells caused GM proliferation in a manner reminiscent of LPS treatment. However, the miR-155–induced GM populations displayed pathological features characteristic of myeloid neoplasia. Of possible relevance to human disease, miR-155 was found to be overexpressed in the bone marrow of patients with certain subtypes of acute myeloid leukemia (AML). Furthermore, miR-155 repressed a subset of genes implicated in hematopoietic development and disease. These data implicate miR-155 as a contributor to physiological GM expansion during inflammation and to certain pathological features associated with AML, emphasizing the importance of proper miR-155 regulation in developing myeloid cells during times of inflammatory stress. The Rockefeller University Press 2008-03-17 /pmc/articles/PMC2275382/ /pubmed/18299402 http://dx.doi.org/10.1084/jem.20072108 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles O'Connell, Ryan M. Rao, Dinesh S. Chaudhuri, Aadel A. Boldin, Mark P. Taganov, Konstantin D. Nicoll, John Paquette, Ronald L. Baltimore, David Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder |
title | Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder |
title_full | Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder |
title_fullStr | Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder |
title_full_unstemmed | Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder |
title_short | Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder |
title_sort | sustained expression of microrna-155 in hematopoietic stem cells causes a myeloproliferative disorder |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275382/ https://www.ncbi.nlm.nih.gov/pubmed/18299402 http://dx.doi.org/10.1084/jem.20072108 |
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