Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe

Motor neurons regulate the acetylcholine sensitivity of the muscles they innervate: denervated muscle fiber become "supersensitive" to acetylcholine, due to insertion of newly synthesized acetylcholine receptors (AChRs) in the plasma membrane. We used hybridization analysis with a cloned c...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1984
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275635/
https://www.ncbi.nlm.nih.gov/pubmed/6547444
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collection PubMed
description Motor neurons regulate the acetylcholine sensitivity of the muscles they innervate: denervated muscle fiber become "supersensitive" to acetylcholine, due to insertion of newly synthesized acetylcholine receptors (AChRs) in the plasma membrane. We used hybridization analysis with a cloned cDNA specific for AChR alpha-subunit to compare the abundance of AChR mRNA in innervated and denervated adult mouse muscles. Within 3 d of denervation, levels of AChR mRNA increased 100- fold; levels of actin mRNA changed little. The increase in AChR mRNA level was sufficiently large and rapid to account for denervation supersensitivity.
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spelling pubmed-22756352008-05-01 Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe J Cell Biol Articles Motor neurons regulate the acetylcholine sensitivity of the muscles they innervate: denervated muscle fiber become "supersensitive" to acetylcholine, due to insertion of newly synthesized acetylcholine receptors (AChRs) in the plasma membrane. We used hybridization analysis with a cloned cDNA specific for AChR alpha-subunit to compare the abundance of AChR mRNA in innervated and denervated adult mouse muscles. Within 3 d of denervation, levels of AChR mRNA increased 100- fold; levels of actin mRNA changed little. The increase in AChR mRNA level was sufficiently large and rapid to account for denervation supersensitivity. The Rockefeller University Press 1984-07-01 /pmc/articles/PMC2275635/ /pubmed/6547444 Text en Copyright © 1984, This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe
title Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe
title_full Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe
title_fullStr Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe
title_full_unstemmed Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe
title_short Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe
title_sort denervation supersensitivity in skeletal muscle: analysis with a cloned cdna probe
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275635/
https://www.ncbi.nlm.nih.gov/pubmed/6547444

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