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Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats

Medicinal plants constitute an important source of potential therapeutic agents for diabetes. In the present study, we investigated the effects of Moringa oleifera (MO) Lam, Moringacea, on glucose tolerance in Wistar rats and Goto-Kakizaki (GK) rats, modeled type 2 diabetes. Major polyphenols in MO...

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Autores principales: Ndong, Moussa, Uehara, Mariko, Katsumata, Shin-ichi, Suzuki, Kazuharu
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275769/
https://www.ncbi.nlm.nih.gov/pubmed/18398501
http://dx.doi.org/10.3164/jcbn.40.229
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author Ndong, Moussa
Uehara, Mariko
Katsumata, Shin-ichi
Suzuki, Kazuharu
author_facet Ndong, Moussa
Uehara, Mariko
Katsumata, Shin-ichi
Suzuki, Kazuharu
author_sort Ndong, Moussa
collection PubMed
description Medicinal plants constitute an important source of potential therapeutic agents for diabetes. In the present study, we investigated the effects of Moringa oleifera (MO) Lam, Moringacea, on glucose tolerance in Wistar rats and Goto-Kakizaki (GK) rats, modeled type 2 diabetes. Major polyphenols in MO powder were quercetin glucosides, rutin, kaempferol glycosides and chlorogenic acids by HPLC analysis. As the results of glucose tolerance test, MO significantly decreased the blood glucose at 20, 30, 45and 60 min for GK rats and at 10, 30 and 45 min for Wistar rats (p<0.05) compared to the both controls after glucose administration. The area under the curve of changes in the blood glucose was significantly higher in the GK control group than in the GK plus MO group (p<0.05) in the periods 30–60 min and 60–120 min. Furthermore, MO significantly decreased stomach emptying in GK rats (p<0.05). The results indicated that MO has an ameliorating effect for glucose intolerance, and the effect might be mediated by quercetin-3-glucoside and fiber contents in MO leaf powder. The action of MO was greater in GK rats than in Wistar rats.
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spelling pubmed-22757692008-04-08 Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats Ndong, Moussa Uehara, Mariko Katsumata, Shin-ichi Suzuki, Kazuharu J Clin Biochem Nutr Original Article Medicinal plants constitute an important source of potential therapeutic agents for diabetes. In the present study, we investigated the effects of Moringa oleifera (MO) Lam, Moringacea, on glucose tolerance in Wistar rats and Goto-Kakizaki (GK) rats, modeled type 2 diabetes. Major polyphenols in MO powder were quercetin glucosides, rutin, kaempferol glycosides and chlorogenic acids by HPLC analysis. As the results of glucose tolerance test, MO significantly decreased the blood glucose at 20, 30, 45and 60 min for GK rats and at 10, 30 and 45 min for Wistar rats (p<0.05) compared to the both controls after glucose administration. The area under the curve of changes in the blood glucose was significantly higher in the GK control group than in the GK plus MO group (p<0.05) in the periods 30–60 min and 60–120 min. Furthermore, MO significantly decreased stomach emptying in GK rats (p<0.05). The results indicated that MO has an ameliorating effect for glucose intolerance, and the effect might be mediated by quercetin-3-glucoside and fiber contents in MO leaf powder. The action of MO was greater in GK rats than in Wistar rats. the Society for Free Radical Research Japan 2007-05 2007-04-25 /pmc/articles/PMC2275769/ /pubmed/18398501 http://dx.doi.org/10.3164/jcbn.40.229 Text en Copyright © 2007 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ndong, Moussa
Uehara, Mariko
Katsumata, Shin-ichi
Suzuki, Kazuharu
Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats
title Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats
title_full Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats
title_fullStr Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats
title_full_unstemmed Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats
title_short Effects of Oral Administration of Moringa oleifera Lam on Glucose Tolerance in Goto-Kakizaki and Wistar Rats
title_sort effects of oral administration of moringa oleifera lam on glucose tolerance in goto-kakizaki and wistar rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275769/
https://www.ncbi.nlm.nih.gov/pubmed/18398501
http://dx.doi.org/10.3164/jcbn.40.229
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