Cargando…
The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous host cell factors have been implicated in its formation. In particular, recent results have highlighted an important role for the integrase-interactor lens epithelium-derived growth factor (LEDGF)/p75 in lentivi...
Autores principales: | Engelman, Alan, Cherepanov, Peter |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275779/ https://www.ncbi.nlm.nih.gov/pubmed/18369482 http://dx.doi.org/10.1371/journal.ppat.1000046 |
Ejemplares similares
-
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
por: Cherepanov, Peter
Publicado: (2007) -
A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
por: Hare, Stephen, et al.
Publicado: (2009) -
Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses
por: Wang, Hao, et al.
Publicado: (2014) -
The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights
por: Hare, Stephen, et al.
Publicado: (2009) -
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor
por: Wang, Hao, et al.
Publicado: (2012)