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Fusion of a scid Pre-B Cell with a Wild Type (Myeloma) B Cell Results in Correct Rearrangement of a V(D)J Recombination Substrate
Mice with the scid mutation have a defect in the V(D)J recombinase. In order to determine whether the SCID product is normally present in mature B cells that do not have the recombinase activity, scid pre-B cells were fused with myeloma cells. It was found that in the hybrid cells, a rearrangement t...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
1992
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275866/ https://www.ncbi.nlm.nih.gov/pubmed/1343097 http://dx.doi.org/10.1155/1992/84537 |