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Differential Expression Of Adhesion Molecules Within The Human Thymus
Development of a diverse, MHC-restricted yet self-tolerant T-cell repertoire occurs within the thymus, and requires contact between developing T cells and their stromal microenvironment. Such interactions are likely to depend on the combinatorial effect of specific adhesion molecules. As a prelimina...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1994
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275941/ https://www.ncbi.nlm.nih.gov/pubmed/7620326 http://dx.doi.org/10.1155/1994/49301 |
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author | Reza, Julie Naima Ritter, Mary A. |
author_facet | Reza, Julie Naima Ritter, Mary A. |
author_sort | Reza, Julie Naima |
collection | PubMed |
description | Development of a diverse, MHC-restricted yet self-tolerant T-cell repertoire occurs within the thymus, and requires contact between developing T cells and their stromal microenvironment. Such interactions are likely to depend on the combinatorial effect of specific adhesion molecules. As a preliminary step to determining their role in T-cell development, we have studied the distribution of LFA-1/ICAM-1, CD2/LFA-3, VLA-4/VCAM-1, and HECA 452-antigen/E-Selectin ligand pairs on frozen sections of human thymus. Using two color-immunohistochemistry, and a variety of cell-lineage markers that reveal the nature of the cells on which these adhesion molecules are located, we find a differential distribution of adhesion molecules, with some being shared by both endothelial and epithelial cells. We also identify the VCAM-1-positive subpopulation as cortical macrophages. The relevance of these findings to thymopoiesis is discussed. |
format | Text |
id | pubmed-2275941 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1994 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22759412008-03-31 Differential Expression Of Adhesion Molecules Within The Human Thymus Reza, Julie Naima Ritter, Mary A. Dev Immunol Research Article Development of a diverse, MHC-restricted yet self-tolerant T-cell repertoire occurs within the thymus, and requires contact between developing T cells and their stromal microenvironment. Such interactions are likely to depend on the combinatorial effect of specific adhesion molecules. As a preliminary step to determining their role in T-cell development, we have studied the distribution of LFA-1/ICAM-1, CD2/LFA-3, VLA-4/VCAM-1, and HECA 452-antigen/E-Selectin ligand pairs on frozen sections of human thymus. Using two color-immunohistochemistry, and a variety of cell-lineage markers that reveal the nature of the cells on which these adhesion molecules are located, we find a differential distribution of adhesion molecules, with some being shared by both endothelial and epithelial cells. We also identify the VCAM-1-positive subpopulation as cortical macrophages. The relevance of these findings to thymopoiesis is discussed. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2275941/ /pubmed/7620326 http://dx.doi.org/10.1155/1994/49301 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Reza, Julie Naima Ritter, Mary A. Differential Expression Of Adhesion Molecules Within The Human Thymus |
title | Differential Expression Of Adhesion Molecules Within The
Human Thymus |
title_full | Differential Expression Of Adhesion Molecules Within The
Human Thymus |
title_fullStr | Differential Expression Of Adhesion Molecules Within The
Human Thymus |
title_full_unstemmed | Differential Expression Of Adhesion Molecules Within The
Human Thymus |
title_short | Differential Expression Of Adhesion Molecules Within The
Human Thymus |
title_sort | differential expression of adhesion molecules within the
human thymus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275941/ https://www.ncbi.nlm.nih.gov/pubmed/7620326 http://dx.doi.org/10.1155/1994/49301 |
work_keys_str_mv | AT rezajulienaima differentialexpressionofadhesionmoleculeswithinthehumanthymus AT rittermarya differentialexpressionofadhesionmoleculeswithinthehumanthymus |