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Frequency of T-Cell Progenitors in Nude Mice
The hypothesis that prothymocytes are distinct from and regulated independently of multilineage hemopoietic progenitors was tested by enumeration of these two cell populations in normal versus congenitally athymic (nude) mice. The absence of a thymus and of peripheral T cells in nude mice had no eff...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
1995
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275962/ https://www.ncbi.nlm.nih.gov/pubmed/8924761 http://dx.doi.org/10.1155/1995/89597 |
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author | Crispe, I. Nicholas |
author_facet | Crispe, I. Nicholas |
author_sort | Crispe, I. Nicholas |
collection | PubMed |
description | The hypothesis that prothymocytes are distinct from and regulated independently of multilineage hemopoietic progenitors was tested by enumeration of these two cell populations in normal versus congenitally athymic (nude) mice. The absence of a thymus and of peripheral T cells in nude mice had no effect on the frequency of either multilineage progenitors (day 12 CFU-S) or prothymocytes (CFU-T), suggesting that there is no feedback regulation of CFU-T frequency. Thymus seeding from the bone marrow is therefore likely to be regulated by the availability of niches for prothymocyte maturation, rather than by feedback control of prothymocyte production. |
format | Text |
id | pubmed-2275962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1995 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-22759622008-03-31 Frequency of T-Cell Progenitors in Nude Mice Crispe, I. Nicholas Dev Immunol Research Article The hypothesis that prothymocytes are distinct from and regulated independently of multilineage hemopoietic progenitors was tested by enumeration of these two cell populations in normal versus congenitally athymic (nude) mice. The absence of a thymus and of peripheral T cells in nude mice had no effect on the frequency of either multilineage progenitors (day 12 CFU-S) or prothymocytes (CFU-T), suggesting that there is no feedback regulation of CFU-T frequency. Thymus seeding from the bone marrow is therefore likely to be regulated by the availability of niches for prothymocyte maturation, rather than by feedback control of prothymocyte production. Hindawi Publishing Corporation 1995 /pmc/articles/PMC2275962/ /pubmed/8924761 http://dx.doi.org/10.1155/1995/89597 Text en Copyright © 1995 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Crispe, I. Nicholas Frequency of T-Cell Progenitors in Nude Mice |
title | Frequency of T-Cell Progenitors in Nude Mice |
title_full | Frequency of T-Cell Progenitors in Nude Mice |
title_fullStr | Frequency of T-Cell Progenitors in Nude Mice |
title_full_unstemmed | Frequency of T-Cell Progenitors in Nude Mice |
title_short | Frequency of T-Cell Progenitors in Nude Mice |
title_sort | frequency of t-cell progenitors in nude mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275962/ https://www.ncbi.nlm.nih.gov/pubmed/8924761 http://dx.doi.org/10.1155/1995/89597 |
work_keys_str_mv | AT crispeinicholas frequencyoftcellprogenitorsinnudemice |