Tolerance in TCR/Cognate Antigen Double-Transgenic Mice Mediated by Incomplete Thymic Deletion and Peripheral Receptor Downregulation

Influenza nucleoprotein (NP)-specific T-cell receptor transgenic mice (F5) were crossed with transgenic mice expressing the cognate antigenic protein under the control of the H- 2K(b) promoter. Double-transgenic mice show negative selection of thymocytes at the CD4(+)8(+)TCR(10) to CD4(+)8(+)TCR(hi)...

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Detalles Bibliográficos
Autores principales: Mamalaki, Clio, Murdjeva, Marianna, Tolaini, Mauro, Norton, Trisha, Chandler, Phillip, Townsend, Alain, Simpson, Elizabeth, Kioussis, Dimitris
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1995
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275967/
https://www.ncbi.nlm.nih.gov/pubmed/8924765
http://dx.doi.org/10.1155/1995/54219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275967/
https://www.ncbi.nlm.nih.gov/pubmed/8924765
http://dx.doi.org/10.1155/1995/54219

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