Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells

Pro-B cells are early B-cell progenitors that retain macrophage potential. We have studied MHC class II molecules and invariant chain inducibility on four class II negative mouse pro- B-cell clones. We analyzed the effects of IL-4 and IFN-γ, which represent the major inducers of class II in the B-ly...

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Detalles Bibliográficos
Autores principales: Lombard-Platet, Suzanne, Meyer, Valerie, Ceredig, Rhodri
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275979/
https://www.ncbi.nlm.nih.gov/pubmed/9587711
http://dx.doi.org/10.1155/1997/76506
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author Lombard-Platet, Suzanne
Meyer, Valerie
Ceredig, Rhodri
author_facet Lombard-Platet, Suzanne
Meyer, Valerie
Ceredig, Rhodri
author_sort Lombard-Platet, Suzanne
collection PubMed
description Pro-B cells are early B-cell progenitors that retain macrophage potential. We have studied MHC class II molecules and invariant chain inducibility on four class II negative mouse pro- B-cell clones. We analyzed the effects of IL-4 and IFN-γ, which represent the major inducers of class II in the B-lymphoid and monocytic/macrophage lineages, respectively. After 48 h of treatment with either cytokine, three pro-B-cell clones (C2.13, A1.5, and F2.2) expressed intracellular invariant chain and cell-surface class II molecules. One clone (D2.1) remained negative. As already reported, more differentiated 70Z/3 pre-B cells were inducible by IL-4 only. These data suggest that the induction of class II and invariant-chain genes are subject to regulation throughout B-cell differentiation.
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spelling pubmed-22759792008-03-31 Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells Lombard-Platet, Suzanne Meyer, Valerie Ceredig, Rhodri Dev Immunol Research Article Pro-B cells are early B-cell progenitors that retain macrophage potential. We have studied MHC class II molecules and invariant chain inducibility on four class II negative mouse pro- B-cell clones. We analyzed the effects of IL-4 and IFN-γ, which represent the major inducers of class II in the B-lymphoid and monocytic/macrophage lineages, respectively. After 48 h of treatment with either cytokine, three pro-B-cell clones (C2.13, A1.5, and F2.2) expressed intracellular invariant chain and cell-surface class II molecules. One clone (D2.1) remained negative. As already reported, more differentiated 70Z/3 pre-B cells were inducible by IL-4 only. These data suggest that the induction of class II and invariant-chain genes are subject to regulation throughout B-cell differentiation. Hindawi Publishing Corporation 1997 /pmc/articles/PMC2275979/ /pubmed/9587711 http://dx.doi.org/10.1155/1997/76506 Text en Copyright © 1997 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lombard-Platet, Suzanne
Meyer, Valerie
Ceredig, Rhodri
Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
title Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
title_full Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
title_fullStr Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
title_full_unstemmed Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
title_short Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
title_sort both ifn-γ and il-4 induce mhc class ii expression at the surface of mouse pro-b cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275979/
https://www.ncbi.nlm.nih.gov/pubmed/9587711
http://dx.doi.org/10.1155/1997/76506
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AT meyervalerie bothifngandil4inducemhcclassiiexpressionatthesurfaceofmouseprobcells
AT ceredigrhodri bothifngandil4inducemhcclassiiexpressionatthesurfaceofmouseprobcells

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