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MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model

Reconstitution of the T-cell compartment after bone marrow transplantation depends on successful colonization of the thymus by bone-marrow-derived progenitor cells. Recent studies compared the development of syngeneic and allogeneic bone-marrow-derived cells in cocultures with lymphoid-depleted feta...

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Detalles Bibliográficos
Autores principales: Mehr, Ramit, Perelson, Alan S., Sharp, Ayala, Segel, Lee, Globerson, Amiela
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275994/
https://www.ncbi.nlm.nih.gov/pubmed/9814586
http://dx.doi.org/10.1155/1998/65943
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author Mehr, Ramit
Perelson, Alan S.
Sharp, Ayala
Segel, Lee
Globerson, Amiela
author_facet Mehr, Ramit
Perelson, Alan S.
Sharp, Ayala
Segel, Lee
Globerson, Amiela
author_sort Mehr, Ramit
collection PubMed
description Reconstitution of the T-cell compartment after bone marrow transplantation depends on successful colonization of the thymus by bone-marrow-derived progenitor cells. Recent studies compared the development of syngeneic and allogeneic bone-marrow-derived cells in cocultures with lymphoid-depleted fetal thymus explants, leading to the discovery of MHC-linked syngeneic developmental preference (SDP) in the thymus. To determine the nature of cell interactions among the bone marrow and thymic elements that might underlie SDP, we analyzed this phenomenon by mathematical modeling. The results indicate that syngeneic mature T cells, responsible for inducing this preference, probably interfere both with the seeding of allogeneic bone-marrow-derived thymocyte progenitors in the thymic stroma and with their subsequent proliferation. In addition, the possibility of augmented death among the developing allogeneic thymocytes cannot be ruled out.
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spelling pubmed-22759942008-03-31 MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model Mehr, Ramit Perelson, Alan S. Sharp, Ayala Segel, Lee Globerson, Amiela Dev Immunol Research Article Reconstitution of the T-cell compartment after bone marrow transplantation depends on successful colonization of the thymus by bone-marrow-derived progenitor cells. Recent studies compared the development of syngeneic and allogeneic bone-marrow-derived cells in cocultures with lymphoid-depleted fetal thymus explants, leading to the discovery of MHC-linked syngeneic developmental preference (SDP) in the thymus. To determine the nature of cell interactions among the bone marrow and thymic elements that might underlie SDP, we analyzed this phenomenon by mathematical modeling. The results indicate that syngeneic mature T cells, responsible for inducing this preference, probably interfere both with the seeding of allogeneic bone-marrow-derived thymocyte progenitors in the thymic stroma and with their subsequent proliferation. In addition, the possibility of augmented death among the developing allogeneic thymocytes cannot be ruled out. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2275994/ /pubmed/9814586 http://dx.doi.org/10.1155/1998/65943 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mehr, Ramit
Perelson, Alan S.
Sharp, Ayala
Segel, Lee
Globerson, Amiela
MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model
title MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model
title_full MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model
title_fullStr MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model
title_full_unstemmed MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model
title_short MHC-Linked Syngeneic Developmental Preference in Thymic Lobes Colonized with Bone Marrow Cells: A Mathematical model
title_sort mhc-linked syngeneic developmental preference in thymic lobes colonized with bone marrow cells: a mathematical model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275994/
https://www.ncbi.nlm.nih.gov/pubmed/9814586
http://dx.doi.org/10.1155/1998/65943
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