The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors

On the basis of both the interleukin-2-receptor (IL-2R) α-chain expression on 16-day-old fetal rat thymocytes and the occurrence of interleukin-2 (IL-2) mRNA-containing cells early during rat thymus ontogeny, we have investigated the possible role of IL-2/IL-2R complex in rat T-cell maturation. For...

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Autores principales: Varas, Alberto, Romo, Teresa, Jiménez, Eva, Alonso, Luis, Vicente, Angeles, Zapata, Agustín G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1998
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276011/
https://www.ncbi.nlm.nih.gov/pubmed/9716915
http://dx.doi.org/10.1155/1998/95861
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author Varas, Alberto
Romo, Teresa
Jiménez, Eva
Alonso, Luis
Vicente, Angeles
Zapata, Agustín G.
author_facet Varas, Alberto
Romo, Teresa
Jiménez, Eva
Alonso, Luis
Vicente, Angeles
Zapata, Agustín G.
author_sort Varas, Alberto
collection PubMed
description On the basis of both the interleukin-2-receptor (IL-2R) α-chain expression on 16-day-old fetal rat thymocytes and the occurrence of interleukin-2 (IL-2) mRNA-containing cells early during rat thymus ontogeny, we have investigated the possible role of IL-2/IL-2R complex in rat T-cell maturation. For this purpose, we analyzed the effects of the addition of either recombinant rat IL- 2 or anti-CD25 (OX-39)-blocking monoclonal antibodies to fetal thymus organ cultures (FTOC), established from 16-day-old rat embryos. IL-2 stimulated the growth of thymocytes and, as a result, induced T-cell differentiation, whereas OX-39 mAb blocked the maturation of thymic-cell progenitors. Accordingly, these results support the involvement of IL-2/IL-2R complex in rat Tcell development.
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spelling pubmed-22760112008-03-31 The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors Varas, Alberto Romo, Teresa Jiménez, Eva Alonso, Luis Vicente, Angeles Zapata, Agustín G. Dev Immunol Research Article On the basis of both the interleukin-2-receptor (IL-2R) α-chain expression on 16-day-old fetal rat thymocytes and the occurrence of interleukin-2 (IL-2) mRNA-containing cells early during rat thymus ontogeny, we have investigated the possible role of IL-2/IL-2R complex in rat T-cell maturation. For this purpose, we analyzed the effects of the addition of either recombinant rat IL- 2 or anti-CD25 (OX-39)-blocking monoclonal antibodies to fetal thymus organ cultures (FTOC), established from 16-day-old rat embryos. IL-2 stimulated the growth of thymocytes and, as a result, induced T-cell differentiation, whereas OX-39 mAb blocked the maturation of thymic-cell progenitors. Accordingly, these results support the involvement of IL-2/IL-2R complex in rat Tcell development. Hindawi Publishing Corporation 1998 /pmc/articles/PMC2276011/ /pubmed/9716915 http://dx.doi.org/10.1155/1998/95861 Text en Copyright © 1998 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Varas, Alberto
Romo, Teresa
Jiménez, Eva
Alonso, Luis
Vicente, Angeles
Zapata, Agustín G.
The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors
title The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors
title_full The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors
title_fullStr The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors
title_full_unstemmed The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors
title_short The IL-2/IL-2-Receptor Complex in the Maturation of Rat T-Cell Progenitors
title_sort il-2/il-2-receptor complex in the maturation of rat t-cell progenitors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276011/
https://www.ncbi.nlm.nih.gov/pubmed/9716915
http://dx.doi.org/10.1155/1998/95861
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