Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates

The immune response of the neonate is poor and is dependent on passive immunity provided by maternal Ig. However, here we show that exposure of the neonate to environmental antigens induces a germinal center (GC) reaction. In the peripheral blood of premature infants one finds IgG class switched B c...

Descripción completa

Detalles Bibliográficos
Autores principales: Wittenbrink, N., Zemlin, M., Bauer, K., Berek, C.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276100/
https://www.ncbi.nlm.nih.gov/pubmed/12885159
http://dx.doi.org/10.1080/1044667031000137665
_version_ 1782151968401129472
author Wittenbrink, N.
Zemlin, M.
Bauer, K.
Berek, C.
author_facet Wittenbrink, N.
Zemlin, M.
Bauer, K.
Berek, C.
author_sort Wittenbrink, N.
collection PubMed
description The immune response of the neonate is poor and is dependent on passive immunity provided by maternal Ig. However, here we show that exposure of the neonate to environmental antigens induces a germinal center (GC) reaction. In the peripheral blood of premature infants one finds IgG class switched B cells expressing a selected V-gene repertoire. These data suggest that restrictions in the repertoire rather than immaturity of the immune system is responsible for the poor immune responses of the neonate.
format Text
id pubmed-2276100
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-22761002008-03-31 Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates Wittenbrink, N. Zemlin, M. Bauer, K. Berek, C. Dev Immunol Research Article The immune response of the neonate is poor and is dependent on passive immunity provided by maternal Ig. However, here we show that exposure of the neonate to environmental antigens induces a germinal center (GC) reaction. In the peripheral blood of premature infants one finds IgG class switched B cells expressing a selected V-gene repertoire. These data suggest that restrictions in the repertoire rather than immaturity of the immune system is responsible for the poor immune responses of the neonate. Hindawi Publishing Corporation 2002-09 /pmc/articles/PMC2276100/ /pubmed/12885159 http://dx.doi.org/10.1080/1044667031000137665 Text en Copyright © 2002 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wittenbrink, N.
Zemlin, M.
Bauer, K.
Berek, C.
Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates
title Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates
title_full Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates
title_fullStr Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates
title_full_unstemmed Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates
title_short Exposure to Environmental Antigens Induces the Development of Germinal Centers in Premature Neonates
title_sort exposure to environmental antigens induces the development of germinal centers in premature neonates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276100/
https://www.ncbi.nlm.nih.gov/pubmed/12885159
http://dx.doi.org/10.1080/1044667031000137665
work_keys_str_mv AT wittenbrinkn exposuretoenvironmentalantigensinducesthedevelopmentofgerminalcentersinprematureneonates
AT zemlinm exposuretoenvironmentalantigensinducesthedevelopmentofgerminalcentersinprematureneonates
AT bauerk exposuretoenvironmentalantigensinducesthedevelopmentofgerminalcentersinprematureneonates
AT berekc exposuretoenvironmentalantigensinducesthedevelopmentofgerminalcentersinprematureneonates

Ejemplares similares