Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

BACKGROUND: The vaccinia virus (VV) F2L gene encodes a functional deoxyuridine triphosphatase (dUTPase) that catalyzes the conversion of dUTP to dUMP and is thought to minimize the incorporation of deoxyuridine residues into the viral genome. Previous studies with with a complex, multigene deletion...

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Detalles Bibliográficos
Autores principales: Prichard, Mark N, Kern, Earl R, Quenelle, Debra C, Keith, Kathy A, Moyer, Richard W, Turner, Peter C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276199/
https://www.ncbi.nlm.nih.gov/pubmed/18321387
http://dx.doi.org/10.1186/1743-422X-5-39

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