Nasal NK/T-cell lymphoma: epidemiology and pathogenesis

Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein–Barr virus (EBV) infection. Analyses of gene m...

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Detalles Bibliográficos
Autores principales: Aozasa, Katsuyuki, Takakuwa, Tetsuya, Hongyo, Tadashi, Yang, Woo-Ick
Formato: Texto
Lenguaje:English
Publicado: Springer Japan 2008
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276242/
https://www.ncbi.nlm.nih.gov/pubmed/18256789
http://dx.doi.org/10.1007/s12185-008-0021-7
Descripción
Sumario:Nasal NK/T-cell lymphoma (NKTCL) is an uncommon disease, but usually shows a highly aggressive clinical course. The disease is much more frequent in Asian and Latin American countries than in Western countries, and is universally associated with Epstein–Barr virus (EBV) infection. Analyses of gene mutations, especially p53 and c-KIT, revealed the different frequencies by district. Epidemiological studies revealed the changes of the disease frequency in Korea during the period from 1977–1989 to 1990–1996. Case-control study showed that the exposure to pesticides and chemical solvents could be causative of NKTCL. Further studies including HLA antigen typing of patients is necessary to further clarify the disease mechanism.

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