Cargando…

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations

Factor H is a regulatory glycoprotein of the complement system. We expressed the three N-terminal complement control protein modules of human factor H (FH1-3) and confirmed FH1-3 to be the minimal unit with cofactor activity for C3b proteolysis by factor I. We reconstructed FH1-3 from NMR-derived st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hocking, Henry G., Herbert, Andrew P., Kavanagh, David, Soares, Dinesh C., Ferreira, Viviana P., Pangburn, Michael K., Uhrín, Dusan, Barlow, Paul N.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276370/ https://www.ncbi.nlm.nih.gov/pubmed/18252712 http://dx.doi.org/10.1074/jbc.M709587200

Ejemplares similares

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease
por: McGlinchey, Ryan P., et al.
Publicado: (2019)

Solution NMR Structure of the Ca(2+)-bound N-terminal Domain of CaBP7: A REGULATOR OF GOLGI TRAFFICKING
por: McCue, Hannah V., et al.
Publicado: (2012)

Engineering Novel Complement Activity into a Pulmonary Surfactant Protein
por: Venkatraman Girija, Umakhanth, et al.
Publicado: (2010)

N-terminal Domain of Prion Protein Directs Its Oligomeric Association
por: Trevitt, Clare R., et al.
Publicado: (2014)

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer
por: Pedrote, Murilo M., et al.
Publicado: (2018)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain
por: Hexnerová, Rozálie, et al.
Publicado: (2016)

Conformational flexibility within the nascent polypeptide–associated complex enables its interactions with structurally diverse client proteins
por: Martin, Esther M., et al.
Publicado: (2018)

Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations
por: Meyer, Virginia, et al.
Publicado: (2016)

Cross-seeding and Conformational Selection between Three- and Four-repeat Human Tau Proteins
por: Yu, Xiang, et al.
Publicado: (2012)

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
por: Kumar, Satish, et al.
Publicado: (2014)

Near-planar Solution Structures of Mannose-binding Lectin Oligomers Provide Insight on Activation of Lectin Pathway of Complement
por: Miller, Ami, et al.
Publicado: (2012)

Structural model of dodecameric heat-shock protein Hsp21: Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity
por: Rutsdottir, Gudrun, et al.
Publicado: (2017)

Using Intramolecular Disulfide Bonds in Tau Protein to Deduce Structural Features of Aggregation-resistant Conformations
por: Walker, Sophie, et al.
Publicado: (2012)

A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von willebrand factor
por: South, Kieron, et al.
Publicado: (2017)

Human Mitochondrial Chaperone (mtHSP70) and Cysteine Desulfurase (NFS1) Bind Preferentially to the Disordered Conformation, Whereas Co-chaperone (HSC20) Binds to the Structured Conformation of the Iron-Sulfur Cluster Scaffold Protein (ISCU)
por: Cai, Kai, et al.
Publicado: (2013)

An Undecided Coiled Coil: THE LEUCINE ZIPPER OF Nek2 KINASE EXHIBITS ATYPICAL CONFORMATIONAL EXCHANGE DYNAMICS
por: Croasdale, Rebecca, et al.
Publicado: (2011)

Evidence That GH115 α-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility
por: Rogowski, Artur, et al.
Publicado: (2014)

Mutations in the Carboxyl-terminal SEC24 Binding Motif of the Serotonin Transporter Impair Folding of the Transporter
por: El-Kasaby, Ali, et al.
Publicado: (2010)

The Mitosis and Neurodevelopment Proteins NDE1 and NDEL1 Form Dimers, Tetramers, and Polymers with a Folded Back Structure in Solution
por: Soares, Dinesh C., et al.
Publicado: (2012)

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation
por: Liu, Jinsong, et al.
Publicado: (2012)

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein (HOP)
por: Yamamoto, Soh, et al.
Publicado: (2014)

Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG
por: McDowell, Melanie A., et al.
Publicado: (2011)

The N-terminal region of RTP1S plays important roles in dimer formation and odorant receptor-trafficking
por: Fukutani, Yosuke, et al.
Publicado: (2019)

The C-terminal region of the plasmid partitioning protein TubY is a tetramer that can bind membranes and DNA
por: Hayashi, Ikuko
Publicado: (2020)

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)
por: Koole, Cassandra, et al.
Publicado: (2017)

S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid
Publicado: (2020)

A Model-Structure of a Periplasm-facing State of the NhaA Antiporter Suggests the Molecular Underpinnings of pH-induced Conformational Changes
por: Schushan, Maya, et al.
Publicado: (2012)

The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates
por: Wang, Yi-Ting, et al.
Publicado: (2013)

Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability
por: Houliston, R. Scott, et al.
Publicado: (2017)

Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
por: Noda, Nobuo N., et al.
Publicado: (2012)

Recombinant Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Forms a Dimer through Its C-terminal Domain
por: Yu, I-Mei, et al.
Publicado: (2005)

Deciphering the Ligand-binding Sites in the Borrelia burgdorferi Complement Regulator-acquiring Surface Protein 2 Required for Interactions with the Human Immune Regulators Factor H and Factor H-like Protein 1
por: Siegel, Corinna, et al.
Publicado: (2008)

Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION
por: Hatherley, Deborah, et al.
Publicado: (2009)

Olfactomedin-1 Has a V-shaped Disulfide-linked Tetrameric Structure
por: Pronker, Matti F., et al.
Publicado: (2015)

Organization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking
por: Lee, Jennifer, et al.
Publicado: (2015)

Uncovering the Early Assembly Mechanism for Amyloidogenic β(2)-Microglobulin Using Cross-linking and Native Mass Spectrometry
por: Hall, Zoe, et al.
Publicado: (2016)

Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17
por: Cabedo Martinez, Ana-Isabel, et al.
Publicado: (2016)

Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response
por: Perrett, Sarah
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_hajp12k7ong79rvpgu3gv4kul7