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Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations

Factor H is a regulatory glycoprotein of the complement system. We expressed the three N-terminal complement control protein modules of human factor H (FH1-3) and confirmed FH1-3 to be the minimal unit with cofactor activity for C3b proteolysis by factor I. We reconstructed FH1-3 from NMR-derived st...

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Detalles Bibliográficos
Autores principales:	Hocking, Henry G., Herbert, Andrew P., Kavanagh, David, Soares, Dinesh C., Ferreira, Viviana P., Pangburn, Michael K., Uhrín, Dusan, Barlow, Paul N.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276370/ https://www.ncbi.nlm.nih.gov/pubmed/18252712 http://dx.doi.org/10.1074/jbc.M709587200

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