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Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

BACKGROUND: Parkinson's disease (PD) is the most prevalent incurable neurodegenerative movement disorder. Mutations in LRRK2 are associated with both autosomal dominant familial and sporadic forms of PD. LRRK2 encodes a large putative serine/threonine kinase with GTPase activity. Increased LRRK...

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Detalles Bibliográficos
Autores principales:	Wang, Danling, Tang, Beisha, Zhao, Guohua, Pan, Qian, Xia, Kun, Bodmer, Rolf, Zhang, Zhuohua
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276501/ https://www.ncbi.nlm.nih.gov/pubmed/18257932 http://dx.doi.org/10.1186/1750-1326-3-3

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