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Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
Recently, we reported that lysophosphatidic acid (LPA) induces long-lasting mechanical allodynia and thermal hyperalgesia as well as demyelination and upregulation of pain-related proteins through one of its cognate receptors, LPA(1). In addition, mice lacking the LPA(1 )receptor gene (lpa(1)(-/- )m...
Autores principales: | Inoue, Makoto, Ma, Lin, Aoki, Junken, Chun, Jerold, Ueda, Hiroshi |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277392/ https://www.ncbi.nlm.nih.gov/pubmed/18261210 http://dx.doi.org/10.1186/1744-8069-4-6 |
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