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Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor

BACKGROUND: We have recently shown that epigallocatechin-3-gallate (EGCG), a polyphenolic compound from green tea, inhibits angiogenesis. However, the molecular mechanisms by which EGCG inhibits angiogenesis have never been investigated. In this study, we examined the interaction of PI3K/AKT and MEK...

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Detalles Bibliográficos
Autores principales:	Shankar, Sharmila, Chen, Qinghe, Srivastava, Rakesh K
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278143/ https://www.ncbi.nlm.nih.gov/pubmed/18355401 http://dx.doi.org/10.1186/1750-2187-3-7

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