Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report

Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of th...

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Detalles Bibliográficos
Autores principales: Troncone, Giancarlo, Russo, Maria, Malapelle, Umberto, Accardo, Marina, Ferraro, Angelo, Cozzolino, Immacolata, Palombini, Lucio
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278161/
https://www.ncbi.nlm.nih.gov/pubmed/18353179
http://dx.doi.org/10.1186/1742-6413-5-2
Descripción
Sumario:Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of the BRAF(VK600-1E )mutation, the molecular hallmark of the solid variant of PTC. Histological and molecular evaluation of the surgical specimen confirmed this pre-operative diagnosis. Thus combining cytology to BRAF molecular analysis is useful to refine the cytological diagnosis of this variant also on FNC specimens.

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