Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report

Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of th...

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Autores principales: Troncone, Giancarlo, Russo, Maria, Malapelle, Umberto, Accardo, Marina, Ferraro, Angelo, Cozzolino, Immacolata, Palombini, Lucio
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278161/
https://www.ncbi.nlm.nih.gov/pubmed/18353179
http://dx.doi.org/10.1186/1742-6413-5-2
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author Troncone, Giancarlo
Russo, Maria
Malapelle, Umberto
Accardo, Marina
Ferraro, Angelo
Cozzolino, Immacolata
Palombini, Lucio
author_facet Troncone, Giancarlo
Russo, Maria
Malapelle, Umberto
Accardo, Marina
Ferraro, Angelo
Cozzolino, Immacolata
Palombini, Lucio
author_sort Troncone, Giancarlo
collection PubMed
description Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of the BRAF(VK600-1E )mutation, the molecular hallmark of the solid variant of PTC. Histological and molecular evaluation of the surgical specimen confirmed this pre-operative diagnosis. Thus combining cytology to BRAF molecular analysis is useful to refine the cytological diagnosis of this variant also on FNC specimens.
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spelling pubmed-22781612008-04-02 Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report Troncone, Giancarlo Russo, Maria Malapelle, Umberto Accardo, Marina Ferraro, Angelo Cozzolino, Immacolata Palombini, Lucio Cytojournal Case Report Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of the BRAF(VK600-1E )mutation, the molecular hallmark of the solid variant of PTC. Histological and molecular evaluation of the surgical specimen confirmed this pre-operative diagnosis. Thus combining cytology to BRAF molecular analysis is useful to refine the cytological diagnosis of this variant also on FNC specimens. Medknow Publications 2008-03-19 /pmc/articles/PMC2278161/ /pubmed/18353179 http://dx.doi.org/10.1186/1742-6413-5-2 Text en Copyright © 2008 Troncone et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Troncone, Giancarlo
Russo, Maria
Malapelle, Umberto
Accardo, Marina
Ferraro, Angelo
Cozzolino, Immacolata
Palombini, Lucio
Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report
title Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report
title_full Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report
title_fullStr Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report
title_full_unstemmed Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report
title_short Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report
title_sort cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278161/
https://www.ncbi.nlm.nih.gov/pubmed/18353179
http://dx.doi.org/10.1186/1742-6413-5-2
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