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Luminal Ca(2+) Regulation of Single Cardiac Ryanodine Receptors: Insights Provided by Calsequestrin and its Mutants
The luminal Ca2+ regulation of cardiac ryanodine receptor (RyR2) was explored at the single channel level. The luminal Ca2+ and Mg2+ sensitivity of single CSQ2-stripped and CSQ2-associated RyR2 channels was defined. Action of wild-type CSQ2 and of two mutant CSQ2s (R33Q and L167H) was also compared....
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2279168/ https://www.ncbi.nlm.nih.gov/pubmed/18347081 http://dx.doi.org/10.1085/jgp.200709907 |