Production of functionally active Penicillium chrysogenum isopenicillin N synthase in the yeast Hansenula polymorpha

BACKGROUND: β-Lactams like penicillin and cephalosporin are among the oldest known antibiotics used against bacterial infections. Industrially, penicillin is produced by the filamentous fungus Penicillium chrysogenum. Our goal is to introduce the entire penicillin biosynthesis pathway into the methy...

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Detalles Bibliográficos
Autores principales: Gidijala, Loknath, Bovenberg, Roel AL, Klaassen, Paul, van der Klei, Ida J, Veenhuis, Marten, Kiel, Jan AKW
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287180/
https://www.ncbi.nlm.nih.gov/pubmed/18366686
http://dx.doi.org/10.1186/1472-6750-8-29

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