Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.

Detalles Bibliográficos
Autores principales: Meshorer, Eran, Gruenbaum, Yosef
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287275/
https://www.ncbi.nlm.nih.gov/pubmed/18378774
http://dx.doi.org/10.1083/jcb.200802155
Descripción
Sumario:Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.

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