Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.

Detalles Bibliográficos
Autores principales: Meshorer, Eran, Gruenbaum, Yosef
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287275/
https://www.ncbi.nlm.nih.gov/pubmed/18378774
http://dx.doi.org/10.1083/jcb.200802155
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author Meshorer, Eran
Gruenbaum, Yosef
author_facet Meshorer, Eran
Gruenbaum, Yosef
author_sort Meshorer, Eran
collection PubMed
description Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.
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spelling pubmed-22872752008-10-07 Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging Meshorer, Eran Gruenbaum, Yosef J Cell Biol Reviews Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways. The Rockefeller University Press 2008-04-07 /pmc/articles/PMC2287275/ /pubmed/18378774 http://dx.doi.org/10.1083/jcb.200802155 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Meshorer, Eran
Gruenbaum, Yosef
Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
title Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
title_full Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
title_fullStr Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
title_full_unstemmed Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
title_short Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
title_sort gone with the wnt/notch: stem cells in laminopathies, progeria, and aging
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287275/
https://www.ncbi.nlm.nih.gov/pubmed/18378774
http://dx.doi.org/10.1083/jcb.200802155
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AT gruenbaumyosef gonewiththewntnotchstemcellsinlaminopathiesprogeriaandaging

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