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Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287275/ https://www.ncbi.nlm.nih.gov/pubmed/18378774 http://dx.doi.org/10.1083/jcb.200802155 |