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Pushing for answers: is myosin V directly involved in moving mitochondria?

In budding yeast, the actin-based class V myosin motors, Myo2 and Myo4, transport virtually all organelles from mother to bud during cell division. Until recently, it appeared that mitochondria may be an exception, with studies showing that the Arp2/3 complex is required for their movement. However,...

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Detalles Bibliográficos
Autores principales: Valiathan, Rajeshwari R., Weisman, Lois S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287276/
https://www.ncbi.nlm.nih.gov/pubmed/18391069
http://dx.doi.org/10.1083/jcb.200803064
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author Valiathan, Rajeshwari R.
Weisman, Lois S.
author_facet Valiathan, Rajeshwari R.
Weisman, Lois S.
author_sort Valiathan, Rajeshwari R.
collection PubMed
description In budding yeast, the actin-based class V myosin motors, Myo2 and Myo4, transport virtually all organelles from mother to bud during cell division. Until recently, it appeared that mitochondria may be an exception, with studies showing that the Arp2/3 complex is required for their movement. However, several recent studies have proposed that Myo2 has a direct involvement in mitochondria inheritance. In this issue, Altmann et al. (Altmann, K., M. Frank, D. Neumann, S. Jakobs, and B. Westermann. 2008. J. Cell Biol. 181:119–130) provide the strongest support yet that Myo2 and its associated light chain Mlc1 function directly and significantly in both mitochondria–actin interactions and in the movement of mitochondria from mother to bud. The conflicting functions of Arp 2/3 and Myo2 may be reconciled by the existence of multiple pathways involved in mitochondrial transport.
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spelling pubmed-22872762008-10-07 Pushing for answers: is myosin V directly involved in moving mitochondria? Valiathan, Rajeshwari R. Weisman, Lois S. J Cell Biol Reviews In budding yeast, the actin-based class V myosin motors, Myo2 and Myo4, transport virtually all organelles from mother to bud during cell division. Until recently, it appeared that mitochondria may be an exception, with studies showing that the Arp2/3 complex is required for their movement. However, several recent studies have proposed that Myo2 has a direct involvement in mitochondria inheritance. In this issue, Altmann et al. (Altmann, K., M. Frank, D. Neumann, S. Jakobs, and B. Westermann. 2008. J. Cell Biol. 181:119–130) provide the strongest support yet that Myo2 and its associated light chain Mlc1 function directly and significantly in both mitochondria–actin interactions and in the movement of mitochondria from mother to bud. The conflicting functions of Arp 2/3 and Myo2 may be reconciled by the existence of multiple pathways involved in mitochondrial transport. The Rockefeller University Press 2008-04-07 /pmc/articles/PMC2287276/ /pubmed/18391069 http://dx.doi.org/10.1083/jcb.200803064 Text en Copyright © 2008, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Valiathan, Rajeshwari R.
Weisman, Lois S.
Pushing for answers: is myosin V directly involved in moving mitochondria?
title Pushing for answers: is myosin V directly involved in moving mitochondria?
title_full Pushing for answers: is myosin V directly involved in moving mitochondria?
title_fullStr Pushing for answers: is myosin V directly involved in moving mitochondria?
title_full_unstemmed Pushing for answers: is myosin V directly involved in moving mitochondria?
title_short Pushing for answers: is myosin V directly involved in moving mitochondria?
title_sort pushing for answers: is myosin v directly involved in moving mitochondria?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287276/
https://www.ncbi.nlm.nih.gov/pubmed/18391069
http://dx.doi.org/10.1083/jcb.200803064
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