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The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics
The exploration of quantitative variation in complex traits such as gene expression and drug response in human populations has become one of the major priorities for medical genetics. The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derive...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Libertas Academica
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288550/ https://www.ncbi.nlm.nih.gov/pubmed/18392109 |
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author | Zhang, Wei Ratain, Mark J. Dolan, M. Eileen |
author_facet | Zhang, Wei Ratain, Mark J. Dolan, M. Eileen |
author_sort | Zhang, Wei |
collection | PubMed |
description | The exploration of quantitative variation in complex traits such as gene expression and drug response in human populations has become one of the major priorities for medical genetics. The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derived from four major world populations of European, African, Chinese and Japanese ancestry for researchers to associate with various phenotypic data to find genes affecting health, disease and response to drugs. Recent progress in dissecting genetic contribution to natural variation in gene expression within and among human populations and variation in drug response are two examples in which researchers have utilized the HapMap resource. The HapMap Project provides new insights into the human genome and has applicability to pharmacogenomics studies leading to personalized medicine. |
format | Text |
id | pubmed-2288550 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-22885502008-04-04 The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics Zhang, Wei Ratain, Mark J. Dolan, M. Eileen Bioinform Biol Insights Review The exploration of quantitative variation in complex traits such as gene expression and drug response in human populations has become one of the major priorities for medical genetics. The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derived from four major world populations of European, African, Chinese and Japanese ancestry for researchers to associate with various phenotypic data to find genes affecting health, disease and response to drugs. Recent progress in dissecting genetic contribution to natural variation in gene expression within and among human populations and variation in drug response are two examples in which researchers have utilized the HapMap resource. The HapMap Project provides new insights into the human genome and has applicability to pharmacogenomics studies leading to personalized medicine. Libertas Academica 2008-02-01 /pmc/articles/PMC2288550/ /pubmed/18392109 Text en Copyright © 2008 The authors. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Zhang, Wei Ratain, Mark J. Dolan, M. Eileen The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics |
title | The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics |
title_full | The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics |
title_fullStr | The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics |
title_full_unstemmed | The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics |
title_short | The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics |
title_sort | hapmap resource is providing new insights into ourselves and its application to pharmacogenomics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288550/ https://www.ncbi.nlm.nih.gov/pubmed/18392109 |
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