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PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy homeostasis, inflammation, as well as cell proliferation and differentiation. In the past decade, intensive st...

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Detalles Bibliográficos
Autores principales: Yang, Jichun, Chen, Lihong, Zhang, Xiaoyan, Zhou, Yunfeng, Zhang, Dongjuan, Huo, Ming, Guan, Youfei
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288756/
https://www.ncbi.nlm.nih.gov/pubmed/18401459
http://dx.doi.org/10.1155/2008/723243
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author Yang, Jichun
Chen, Lihong
Zhang, Xiaoyan
Zhou, Yunfeng
Zhang, Dongjuan
Huo, Ming
Guan, Youfei
author_facet Yang, Jichun
Chen, Lihong
Zhang, Xiaoyan
Zhou, Yunfeng
Zhang, Dongjuan
Huo, Ming
Guan, Youfei
author_sort Yang, Jichun
collection PubMed
description Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy homeostasis, inflammation, as well as cell proliferation and differentiation. In the past decade, intensive study of PPARs has shed novel insight into prevention and treatment of dyslipidemia, insulin resistance, and type 2 diabetes. Recently, a large body of research revealed that PPARs are also functionally expressed in reproductive organs and various parts of placenta during pregnancy, which strongly suggests that PPARs might play a critical role in reproduction and development, in addition to their central actions in energy homeostasis. In this review, we summarize recent findings elucidating the role of PPARs in female reproduction, with particular focus on evidence from gene knockout and transgenic animal model study.
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spelling pubmed-22887562008-04-09 PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice Yang, Jichun Chen, Lihong Zhang, Xiaoyan Zhou, Yunfeng Zhang, Dongjuan Huo, Ming Guan, Youfei PPAR Res Review Article Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy homeostasis, inflammation, as well as cell proliferation and differentiation. In the past decade, intensive study of PPARs has shed novel insight into prevention and treatment of dyslipidemia, insulin resistance, and type 2 diabetes. Recently, a large body of research revealed that PPARs are also functionally expressed in reproductive organs and various parts of placenta during pregnancy, which strongly suggests that PPARs might play a critical role in reproduction and development, in addition to their central actions in energy homeostasis. In this review, we summarize recent findings elucidating the role of PPARs in female reproduction, with particular focus on evidence from gene knockout and transgenic animal model study. Hindawi Publishing Corporation 2008 2008-04-06 /pmc/articles/PMC2288756/ /pubmed/18401459 http://dx.doi.org/10.1155/2008/723243 Text en Copyright © 2008 Jichun Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yang, Jichun
Chen, Lihong
Zhang, Xiaoyan
Zhou, Yunfeng
Zhang, Dongjuan
Huo, Ming
Guan, Youfei
PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
title PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
title_full PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
title_fullStr PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
title_full_unstemmed PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
title_short PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
title_sort ppars and female reproduction: evidence from genetically manipulated mice
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288756/
https://www.ncbi.nlm.nih.gov/pubmed/18401459
http://dx.doi.org/10.1155/2008/723243
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