Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes

Although the proteins encoded by a single nucleus in multinucleated myotubes have a wide range of distributions within the myofiber, little is known about the distributions of their mRNAs. We have used hybrid myotubes in which one or a few nuclei are derived from myoblasts that express nonmuscle pro...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1992
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289719/
https://www.ncbi.nlm.nih.gov/pubmed/1447288
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collection PubMed
description Although the proteins encoded by a single nucleus in multinucleated myotubes have a wide range of distributions within the myofiber, little is known about the distributions of their mRNAs. We have used hybrid myotubes in which one or a few nuclei are derived from myoblasts that express nonmuscle proteins to investigate this question. We find that three different mRNAs, encoding proteins that are, respectively, nuclear, cytoplasmic, and targeted to the ER, have similar distributions within myotubes. Each is confined to an area within approximately 100 microns of the nucleus that expresses it.
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spelling pubmed-22897192008-05-01 Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes J Cell Biol Articles Although the proteins encoded by a single nucleus in multinucleated myotubes have a wide range of distributions within the myofiber, little is known about the distributions of their mRNAs. We have used hybrid myotubes in which one or a few nuclei are derived from myoblasts that express nonmuscle proteins to investigate this question. We find that three different mRNAs, encoding proteins that are, respectively, nuclear, cytoplasmic, and targeted to the ER, have similar distributions within myotubes. Each is confined to an area within approximately 100 microns of the nucleus that expresses it. The Rockefeller University Press 1992-12-01 /pmc/articles/PMC2289719/ /pubmed/1447288 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes
title Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes
title_full Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes
title_fullStr Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes
title_full_unstemmed Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes
title_short Restricted distribution of mRNA produced from a single nucleus in hybrid myotubes
title_sort restricted distribution of mrna produced from a single nucleus in hybrid myotubes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289719/
https://www.ncbi.nlm.nih.gov/pubmed/1447288

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