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Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait
The genetic control of common traits is rarely deterministic, with many genes contributing only to the chance of developing a given phenotype. This incomplete penetrance is poorly understood and is usually attributed to interactions between genes or interactions between genes and environmental condi...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289839/ https://www.ncbi.nlm.nih.gov/pubmed/18404214 http://dx.doi.org/10.1371/journal.pgen.1000049 |
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author | Ansel, Juliet Bottin, Hélène Rodriguez-Beltran, Camilo Damon, Christelle Nagarajan, Muniyandi Fehrmann, Steffen François, Jean Yvert, Gaël |
author_facet | Ansel, Juliet Bottin, Hélène Rodriguez-Beltran, Camilo Damon, Christelle Nagarajan, Muniyandi Fehrmann, Steffen François, Jean Yvert, Gaël |
author_sort | Ansel, Juliet |
collection | PubMed |
description | The genetic control of common traits is rarely deterministic, with many genes contributing only to the chance of developing a given phenotype. This incomplete penetrance is poorly understood and is usually attributed to interactions between genes or interactions between genes and environmental conditions. Because many traits such as cancer can emerge from rare events happening in one or very few cells, we speculate an alternative and complementary possibility where some genotypes could facilitate these events by increasing stochastic cell-to-cell variations (or ‘noise’). As a very first step towards investigating this possibility, we studied how natural genetic variation influences the level of noise in the expression of a single gene using the yeast S. cerevisiae as a model system. Reproducible differences in noise were observed between divergent genetic backgrounds. We found that noise was highly heritable and placed under a complex genetic control. Scanning the genome, we mapped three Quantitative Trait Loci (QTL) of noise, one locus being explained by an increase in noise when transcriptional elongation was impaired. Our results suggest that the level of stochasticity in particular molecular regulations may differ between multicellular individuals depending on their genotypic background. The complex genetic architecture of noise buffering couples genetic to non-genetic robustness and provides a molecular basis to the probabilistic nature of complex traits. |
format | Text |
id | pubmed-2289839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-22898392008-04-11 Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait Ansel, Juliet Bottin, Hélène Rodriguez-Beltran, Camilo Damon, Christelle Nagarajan, Muniyandi Fehrmann, Steffen François, Jean Yvert, Gaël PLoS Genet Research Article The genetic control of common traits is rarely deterministic, with many genes contributing only to the chance of developing a given phenotype. This incomplete penetrance is poorly understood and is usually attributed to interactions between genes or interactions between genes and environmental conditions. Because many traits such as cancer can emerge from rare events happening in one or very few cells, we speculate an alternative and complementary possibility where some genotypes could facilitate these events by increasing stochastic cell-to-cell variations (or ‘noise’). As a very first step towards investigating this possibility, we studied how natural genetic variation influences the level of noise in the expression of a single gene using the yeast S. cerevisiae as a model system. Reproducible differences in noise were observed between divergent genetic backgrounds. We found that noise was highly heritable and placed under a complex genetic control. Scanning the genome, we mapped three Quantitative Trait Loci (QTL) of noise, one locus being explained by an increase in noise when transcriptional elongation was impaired. Our results suggest that the level of stochasticity in particular molecular regulations may differ between multicellular individuals depending on their genotypic background. The complex genetic architecture of noise buffering couples genetic to non-genetic robustness and provides a molecular basis to the probabilistic nature of complex traits. Public Library of Science 2008-04-11 /pmc/articles/PMC2289839/ /pubmed/18404214 http://dx.doi.org/10.1371/journal.pgen.1000049 Text en Ansel et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Ansel, Juliet Bottin, Hélène Rodriguez-Beltran, Camilo Damon, Christelle Nagarajan, Muniyandi Fehrmann, Steffen François, Jean Yvert, Gaël Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait |
title | Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait |
title_full | Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait |
title_fullStr | Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait |
title_full_unstemmed | Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait |
title_short | Cell-to-Cell Stochastic Variation in Gene Expression Is a Complex Genetic Trait |
title_sort | cell-to-cell stochastic variation in gene expression is a complex genetic trait |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289839/ https://www.ncbi.nlm.nih.gov/pubmed/18404214 http://dx.doi.org/10.1371/journal.pgen.1000049 |
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