Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells

When P19 mouse embryonal carcinoma cells are grown in a serum-free N2 medium on surfaces of tissue culture plastic, they die within two days. The death of these P19 cells is prevented by activin A and basic FGF (bFGF). The cells do not divide under these conditions. However, when P19 cells are cultu...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289893/
https://www.ncbi.nlm.nih.gov/pubmed/1869590
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description When P19 mouse embryonal carcinoma cells are grown in a serum-free N2 medium on surfaces of tissue culture plastic, they die within two days. The death of these P19 cells is prevented by activin A and basic FGF (bFGF). The cells do not divide under these conditions. However, when P19 cells are cultured on substrata of extracellular matrix proteins such as laminin and fibronectin, activin A and bFGF are potent mitogens. These data show that the substratum to which cells are exposed can regulate their mitogenic response to growth factors.
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spelling pubmed-22898932008-05-01 Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells J Cell Biol Articles When P19 mouse embryonal carcinoma cells are grown in a serum-free N2 medium on surfaces of tissue culture plastic, they die within two days. The death of these P19 cells is prevented by activin A and basic FGF (bFGF). The cells do not divide under these conditions. However, when P19 cells are cultured on substrata of extracellular matrix proteins such as laminin and fibronectin, activin A and bFGF are potent mitogens. These data show that the substratum to which cells are exposed can regulate their mitogenic response to growth factors. The Rockefeller University Press 1991-08-02 /pmc/articles/PMC2289893/ /pubmed/1869590 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells
title Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells
title_full Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells
title_fullStr Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells
title_full_unstemmed Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells
title_short Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells
title_sort substratum-growth factor collaborations are required for the mitogenic activities of activin and fgf on embryonal carcinoma cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289893/
https://www.ncbi.nlm.nih.gov/pubmed/1869590

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